The Binding of Isaac: Rebirth (Commonly referred to as Rebirth) is a remake based on the original Flash game, The Binding of Isaac. It was developed by Nicalis with Edmund McMillen in a supervising position, and was released November 4, 2014 on Steam, PlayStation 4, and PlayStation Vita.

Rebirth features a new non-Flash-based engine and the same designs as the original, but with brand new 16-bit pixel graphics. The game also includes additional content in the size of the Wrath of the Lamb expansion, including things that had to be cut from the original game due to the limitations of Flash.